CGRP receptor antagonists

A compound of formula I′:

• or a pharmaceutically acceptable salt thereof;
• wherein:
• said NRA group is attached to the phenyl ring at carbon atom 1 or 2;
• X is O, NRA, S, SO, or SO2;
• RA is hydrogen or C1-C6 aliphatic optionally substituted with up to 4 R1 substituents;
• ring A is a 4-7 membered heterocyclic ring having 1-4 heteroatoms selected from O, N, S, SO, or S(O)2, wherein said heterocyclic ring is optionally fused to a phenyl or a 5-7 membered heterocyclic or heteroaryl ring having 1-4 heteroatoms selected from O, N, S, SO, or S(O)2;
• wherein ring A has at least one oxo substituent;
• wherein ring A, together with the optionally fused ring, is optionally substituted with up to 5 R2 substituents;
• m is 1-3;
• p is 1-3;
• n is 1-4;
• each RX is independently hydrogen, halo, aryl, heteroaryl, C1-C6 aliphatic, C1-C6 heteroaliphatic, aryl-C1-C6 aliphatic, aryl-C1-C6 heteroaliphatic, heteroaryl-C1-C6 aliphatic, heteroaryl-C1-C6 heteroaliphatic, wherein RX is optionally substituted with up to 5 R3 substituents;
• or
• two RX, taken together with the carbon atom that they are attached to, form a 3-9 membered cycloaliphatic or heterocyclic ring, wherein said heterocyclic ring has up to 3 heteroatoms selected from O, S, and N;
• wherein said ring is optionally substituted with up to 3 R3 substituents;
• each RW is independently hydrogen, halo, aryl, heteroaryl, C1-C6 aliphatic, C1-C6 heteroaliphatic, aryl-C1-C6 aliphatic, heteroaryl-C1-C6 aliphatic, wherein RX is optionally substituted with up to 5 R4 substituents;
• or
• two RW, taken together with the carbon atom that they are attached to, form a 3-9 membered cycloaliphatic or heterocyclic ring, wherein said heterocyclic ring has up to 3 heteroatoms selected from O, S, and N;
• wherein said ring is optionally substituted with up to 3 R4 substituents;
• wherein each occurrence of R1, R2, R3, R4, and RY is independently Q—RM;
• wherein Q is a bond or is a C1-C6 aliphatic chain wherein up to two non-adjacent methylene units of Q are optionally replaced by CO, CO2, COCO, CONR, OCONR, NRNR, NRNRCO, NRCO, NRCO2, NRCONR, SO, SO2, NRSO2, SO2NR, NRSO2NR, O, S, or NR;
• wherein each occurrence of RM is independently selected from R′, halogen, NO2, CN, OR′, SR′, N(R′)2, NR′C(O)R′, NR′C(O)N(R′)2, NR′CO2R′, C(O)R′, CO2R′, OC(O)R′, C(O)N(R′)2, OC(O)N(R′)2, SOR′, SO2R′, SO2N(R′)2, NR′SO2R′, NR′SO2N(R′)2, C(O)C(O)R′, or C(O)CH2C(O)R′, wherein each occurrence of R is independently selected from hydrogen or an optionally substituted C1-C6 aliphatic group or C1-C6 heteroaliphatic;
• wherein each occurrence of R′ is independently selected from hydrogen or an optionally substituted group selected from C1-8 aliphatic, C6-10 aryl, a heteroaryl ring having 5-10 ring atoms, or a heterocyclyl ring having 3-10 ring atoms, or wherein R and R′ taken together with the atom(s) to which they are bound, or two occurrences of R′ taken together with the atom(s) to which they are bound, form a 3-8 membered cycloalkyl, heterocyclyl, aryl, or heteroaryl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur.

A compound selected from:

• 1
• 2
• 3
• 4
• 5
• 6
• 7
• 8
• 9
• 10
• 11
• 12
• 13
• 14
• 15
• 16
• 17
• 18
• 19
• 20
• 21
• 22
• 23
• 24
• 25
• 26
• 27
• 28
• 29
• 30
• 31
• 32
• 33
• 34
• 35
• 36
• 37
• 38
• 39
• 40
• 41
• 42
• 43
• 44
• 45
• 46
• 47
• 48
• 49
• 50
• 51
• 52
• 53
• 54
• 55
• 56
• 57
• 58
• 59
• 60
• 61
• 62
• 63
• 64
• 65
• 66
• 67
• 68
• 69
• 70
• 71
• 72
• 73
• 74
• 75
• 76
• 77
• 78
• or