US 7,842,666 B2 · Inhibitors of myelin-associated glycoprotein (MAG) activity for regulating neural growth and regeneration

Abstract

The present invention relates generally to products, compositions and methods useful for promoting neural repair and regeneration. The products and compositions of this invention include myelin-associated glycoprotein (MAG) derivatives that are inhibitors of endogenous MAG (e.g., mutant MAG proteins) and Nogo Receptor (NgR) binding inhibitors that are peptides derived from MAG, Nogo and OMgp that can bind to NgR and block NgR signaling. Peptides that can bind and activate NgR signaling are also provided. Inhibitory MAG derivatives and NgR binding inhibitors are useful for blocking the inhibition of neural regeneration mediated by proteins such as MAG, Nogo and/or OMgp in the nervous system. These inhibitors are also useful for treating neural degeneration associated with injuries, disorders or diseases.

Claims18

Dependent claims

An isolated polypeptide comprising a neuronal binding region consisting of an Ig-like domain 1 (Igd1) of a protein, wherein said protein has at least 75% sequence identity to SEQ ID NO:

2, 4 or 6 and said neuronal binding region is capable of binding said polypeptide to neuronal surfaces;
the polypeptide further comprises at least one of MAG Ig-like domain 5 (Igd5) amino acid residues 432 to 488 and lacks MAG Igd5 amino acid residues 450 to 490 or 450 to 453 of SEQ ID NO:
2, 4, or 6;
and
whereby the ability of the polypeptide to regulate neurite outgrowth as compared to endogenous or soluble MAG is reduced or eliminated.

2 more elements

Dependencies are inferred from the claim text.

Inhibitors of myelin-associated glycoprotein (MAG) activity for regulating neural growth and regeneration

Life of this patent

Inhibitors of myelin-associated glycoprotein (MAG) activity for regulating neural growth and regeneration

Life of this patent

Abstract

Claims18