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US 7,842,664 B2Granted
Synthetic lipid mixtures for the preparation of a reconstituted surfactant
AssigneeChiesi Farmaceutici S.p.A.
InventorsTore Curstedt, Jan Johansson, Bengt Robertson
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Abstract
The invention relates to reconstituted surfactants consisting of artificial phospholipids and peptides able to lower the air-liquid surface tension, more particularly to reconstituted surfactants comprising special phospholipid mixtures and artificial peptides which are analogues of the natural surfactant SP-C protein for the treatment of respiratory distress syndrome (RDS) and other diseases relating to pulmonary surfactant dysfunctions.
Claims20
A reconstituted surfactant, consisting of:
- a) a phospholipid vehicle;
- b) an artificial peptide analog of natural surfactant protein SP-C;
- and
- c) an artificial peptide analog of natural surfactant protein SP-B,
- wherein said vehicle is a mixture consisting of:
- (i) dipalmitoyl phophatidylcholine (DPPC) and (ii) a palmitoyl oleyl phospholipid selected from the group consisting of 1 palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol (POPG) and a mixture of 1 palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol and 1 palmitoyl-2-oleoyl-sn-3-glycero-3-phosphocholine (POPC), in a weight ratio ranging from 80:20 to 60:40, and
- wherein said artificial peptide analog of natural surfactant protein SP-C has the formula (II):
- (SEQ ID NO:
- 2)
- IPSSPVHLKRLKLLLLLLLLILLLILGALLΩGL (II)
- wherein Ω is a residue selected from the group consisting of M, I, L and nL.
8 more elements
Dependencies are inferred from the claim text.