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US 7,842,649 B2Granted
Quality control method for making a biochip displaying an encoded bead array
AssigneeBioArray Solutions, Ltd.
InventorsMichael Seul, Chiu Wo Chau, Hui Huang, Sukanta Banerjee, Jiacheng Yang, Ye Hong
Life of this patent
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Abstract
This invention provides high unit density arrays of microparticles and methods of assembling such arrays. The microparticles in the arrays may be functionalized with chemical or biological entities specific to a given target analyte. The high unit density arrays of this invention are formed on chips which may be combined to form multichip arrays according to the methods described herein. The chips and/or multichip arrays of this invention are useful for chemical and biological assays.
Claims10
A method for quality control of biochip manufacture, comprising:
- exposing a patterned substrate containing a plurality of recesses, each sized for restraining an encoded bio-functionalized microbead, to a solution containing said microbeads under conditions such that microbeads are trapped in the recesses;
- and
- optically imaging the substrate to determine what percentage of recesses are occupied with an encoded microbead.
Dependencies are inferred from the claim text.