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US 7,842,514 B2Granted
Particle manipulation unit, chip and detection device having the same, mounted thereon, and methods of separating, capturing and detecting proteins
AssigneeNEC Corporation
InventorsWataru Hattori, Masakazu Baba, Toru Sano, Kazuhiro Iida, Hisao Kawaura, Noriyuki Iguchi, Hiroko Someya
Life of this patent
Estimating the term…
Abstract
A channel (1) formed in a substrate (41) branches into channels (2, 3) at a branch point (43). On this branch point, obstacles (8) having a columnar structure are aligned at certain intervals.
Claims25
A particle manipulation unit, comprising:
- a substrate;
- a channel formed on said substrate, comprising a first channel and a second channel branched out from said first channel, capable of manipulating direction of flow of particles flowing in a liquid in said channel;
- and
- a permeation limiting zone limiting permeation of at least a part of said particles, disposed in said first channel in the vicinity of a branching point where one or more second channels are branched out from said first channel,
- wherein said permeation limiting zone has a plurality of obstacles arranged to be spaced from each other, the obstacles being selected from the group consisting of cylinders, pseudo-cylinders, cones, circular cones, elliptical cones, prisms, triangular prisms and quadrangular prisms,
- a gap between adjacent obstacles is set to a size allowing a part of said particles to permeate therethrough, and said obstacles are arranged so that a direction of force causing flow of said particles lies non-normal to and non-parallel with a direction of arrangement of said obstacles at the front-most plane on the branching point side of said permeation limiting zone.
3 more elements
A particle manipulation unit, comprising:
- a substrate;
- a channel formed on said substrate, comprising a main channel, and one or more side channels branched out from said main channel towards the downstream side of said main channel, capable of manipulating direction of flow of particles flowing in a liquid in said channel;
- a flow control portion disposed on the upstream side of a branching point where one or more side channels are branched out from said main channel,
- said flow control portion controlling direction of flow of said particles, and guiding at least a part of said particles to either of said main channel and said side channel,
- wherein said flow control portion has a plurality of obstacles periodically arranged, said plurality of obstacles being configured so as to control direction of flow of said particles, and so as to guide at least a part of said particles to either of said main channel and said side channels, depending on the arrangement thereof,
- the obstacles are selected from the group consisting of cylinders, pseudo-cylinders, cones, circular cones, elliptical cones, prisms, triangular prisms and quadrangular prisms, and
- the obstacles are arranged so that a direction of force causing flow of said particles lies non-normal to and non-parallel with a direction of arrangement of said obstacles at a front-most plane on a branching point side of a permeation limiting zone.
4 more elements
A particle manipulation unit, comprising:
- a substrate;
- and
- a channel formed on said substrate, capable of manipulating state of flow of particles flowing in said channel, said channel having a flow control portion which comprises trenches formed on the wall surface of said channel, guiding at least a part of said particles to a predetermined direction,
- wherein said trench structures have a long axis and a short axis oriented neither in parallel nor in normal to a force causing the flow of particles.
1 more element
A particle manipulation unit comprising a substrate, and a channel formed on said substrate, capable of manipulating direction of flow of particles flowing in said channel,
- said channel having, provided thereto, a permeation limiting zone limiting permeation therethrough of at least a part of said particles,
- said permeation limiting zone having a width of entrance narrower than the width of said permeation limiting zone,
- having a first drive means providing said particle flowing in said permeation limiting zone with a migration speed in one direction, and a second drive means providing a migration speed in other direction different from said one direction, and
- said permeation limiting zone being provided with a plurality of obstacles arranged as being spaced from each other,
- wherein the obstacles are selected from the group consisting of cylinders, pseudo-cylinders, cones, circular cones, elliptical cones, prisms, triangular prisms and quadrangular prisms, and
- the obstacles are arranged so that a direction of force causing flow of said particles lies non-normal to and non-parallel with a direction of arrangement of said obstacles at a front-most plane on a branching point side of the permeation limiting zone.
3 more elements
Dependencies are inferred from the claim text.