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US 7,842,498 B2Granted
Hydrophobic surface chip
AssigneeBio-Rad Laboratories, Inc.
InventorsPil-Je Um, Christopher A. Pohl
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Abstract
The invention provides a water-swellable hydrophobic hydrogel and analytical devices incorporating the hydrogel of the invention. Also provided are methods of using the hydrogel to prepare the analytical devices and methods of using the analytical devices to detect, quantitate and discriminate between analytes in a sample. Moreover, the invention provides kits that include components of a hydrogel and instructions for making a chip with a hydrophobic surface.
Claims11
An adsorbent chip comprising:
- (a) a silicon dioxide coated metal substrate comprising a surface;
- and
- (b) an adsorbent layer attached to the surface, wherein the absorbent layer comprises a hydrogel comprising hydrophobic moieties and hydrophilic moieties wherein said hydrogel is formed by co-polymerization of a cross-linking agent and a monomer comprising a nonylphenoxy-poly(oxyethylene),
- wherein the hydrogel is water-swellable and binds an analyte through a salt-independent hydrophobic attraction.
1 more element
An adsorbent chip comprising:
- (a) a silicon dioxide coated metal substrate comprising a surface;
- and
- (b) an adsorbent layer attached to the surface, wherein the absorbent layer comprises a hydrogel comprising hydrophobic moieties and hydrophilic moieties, wherein said hydrogel is formed by co-polymerization of poly(ethylene glycol) dimethacrylate and a monomer having the formula:
- R1 is nonylphenoxy;
- R2 is CH3;
- m is an integer from 2 to 100;
- and
- wherein the hydrogel is water-swellable and binds an analyte through a salt-independent hydrophobic attraction.
5 more elements
Dependencies are inferred from the claim text.