DNA encoding mammalian phosphodiesterases
AssigneeThe Board of Regents of the University of Washington
InventorsJoseph A. Beavo, J. Kelley Bentley, Harry Charbonneau, William K. Sonnenburg
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Abstract
The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca2+/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
Claims9
A purified and isolated polynucleotide comprising the DNA sequence encoding a mammalian cyclic GMP stimulated cyclic nucleotide phosphodiesterase enzyme selected from the group consisting of
- a) the polynucleotide of SEQ ID NO:
- 38;
- and
- b) the polynucleotide of SEQ ID NO:
- 44.
Dependencies are inferred from the claim text.