Tissue repair matrix
AssigneeDePuy Spine, Inc.
InventorsRonald K. Yamamoto, Michael K. Kwan, Stephen D. Pacetti
Life of this patent
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Abstract
A porous three-dimensional tissue repair matrix is provided which is biodegradable. The matrix is preferably formed from mineralized collagen where the mineral comprises particulate calcium phosphate immobilized in the matrix.
Claims14
An implantable porous, biodegradable, three-dimensionally fixed matrix having shape memory comprising a network of water-insoluble mineralized biopolymer fibers, and a water-soluble binder which is adhered to said fibers and rendered insoluble in the matrix by cross-linking;
- wherein said mineralized biopolymer fibers are mineralized by precipitating calcium and phosphate ions in the presence of said biopolymer fibers, and said mineralized biopolymer fibers are immobilized within said matrix by said water-soluble binder;
- and
- wherein said matrix is compressible from an initial size, shape and porosity to a compressed state and returns from said compressed state to said initial size, shape and porosity without substantial loss of said fibers or binder.
An implantable, porous, biodegradable, three-dimensionally fixed matrix for bone growth having shape memory which maintains its porosity for a period greater than about fourteen days after implantation into a physiological environment in which said bone growth is required, comprising insoluble mineralized biopolymer fibers and a water-soluble binder which is adhered to said fibers and rendered insoluble in the matrix by cross-linking;
- wherein said mineralized biopolymer fibers are mineralized by precipitating calcium and phosphate ions in the presence of said biopolymer fibers, and said mineralized biopolymer fibers are immobilized within said matrix by said water-soluble binder;
- and
- wherein said matrix is compressible from an initial size, shape and porosity to a compressed state and returns from said compressed state to said initial size, shape and porosity without substantial loss of said fibers or binder.
Dependencies are inferred from the claim text.