Stimulus regimens for cardiovascular reflex control
AssigneeCVRx, Inc.
InventorsRobert S. Kieval, Bruce J. Persson, David J. Serdar, Peter T. Keith
Life of this patent
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Abstract
Devices, systems and methods by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, for example a baroreceptor in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption.
Claims16
A method of inducing a baroreceptor signal to effect a change in the baroreflex system in a patient, the method comprising the steps of:
- providing a baroreceptor activation device including a first means for outputting an electrical signal to electrically induce a baroreceptor signal and a second means for outputting an electrical signal to electrically induce a baroreceptor signal, the first means for outputting an electrical signal adapted to be positioned proximate a first baroreceptor location and the second means for outputting an electrical signal adapted to be positioned proximate a second baroreceptor location;
- and
- alternating the electrical signal between the first means for outputting and the second means for outputting to promote long term efficacy of inducing baroreceptor signals and reduce exposure of a single baroreceptor location.
A system for inducing a baroreceptor signal to effect a change in the baroreflex system in a patient, the system comprising:
- a baroreceptor activation device including a first means for outputting adapted to be implanted proximate a first baroreceptor location, and a second means for outputting adapted to be positioned proximate a second baroreceptor location, such that activation of the baroreceptor activation device induces a baroreceptor signal in the patient;
- and
- a control system connected to the baroreceptor activation device, the control system including a processor and a memory, wherein the memory includes software defining a stimulus regimen, the control system generating a control signal that activates one of the first means for outputting or the second means for outputting of the baroreceptor activation device as a function of the stimulus regimen, the stimulus regimen causing the control signal to be changed to promote long term efficacy of inducing baroreceptor signals and reduce exposure of a single baroreceptor location by alternating the control signal between the first means for outputting and the second means for outputting.
A method of inducing a baroreceptor signal to effect a change in the baroreflex system in a patient, the method comprising the steps of:
- providing a baroreceptor activation device including a first means for outputting an electrical signal to electrically induce a baroreceptor signal and a second means for outputting an electrical signal to electrically induce a baroreceptor signal, providing instructions for operating the baroreflex activation device, comprising:
- implanting the baroreceptor activation device such that the first means for outputting an electrical signal is proximate a first baroreceptor location in the patient and the second means for outputting an electrical signal is proximate a second baroreceptor location;
- alternating the electrical signal between the first means for outputting and the second means for outputting to promote long term efficacy of inducing baroreceptor signals and reduce exposure of a single baroreceptor location.
Dependencies are inferred from the claim text.