Function of autophagy genes in cell death
AssigneesUniversity of Maryland, College Park, National Institutes of Health
InventorsEric H. Baehrecke, Ajjai Alva, Michael J. Lenardo, Yu Li
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Abstract
The present invention relates to a new molecular pathway in which activation of the receptor-interacting protein (RIP, a serine-threonine kinase) and Jun N-terminal kinase induce cell death with the morphology of autophagy. Further, autophagic death is induced by caspase 8 inhibition and expression of the mammalian genes ATG7 and beclin.
Claims2
A composition comprising a caspase-8 inhibitor comprising antibodies that specifically bind caspase-8 and wherein the composition further comprises at least one polynucleotide sequence encoding a polypeptide which is selected from ATG6, ATG7, Beclin-1, HsGSA7, mAPG7, and APG6.
A composition comprising a caspase-8 inhibitor comprising antibodies that specifically bind caspase-8 and wherein the composition further comprises at least one polynucleotide sequence comprising SEQ ID NO:
- 1, SEQ ID NO:
- 3, SEQ ID NO:
- 18, or SEQ ID NO:
- 20.
Dependencies are inferred from the claim text.