Antibodies to train R: a cysteine-rich member of the TNF-receptor family, and methods of treating tumors expressing said receptor
AssigneesBiogen Idec MA Inc., Apoxis SA
InventorsJurg Tschopp, Catherine Hession
Life of this patent
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Abstract
Embodiments of the present invention encompass novel receptors of the TNF family. In particular, embodiments of the invention encompass TNF Receptor in the BRAIN (TRAIN) and isolated antibodies that bind to the same. In some embodiments, isolated antibodies that bind to TRAIN are useful in regulating cell differentiation, death, and survival. Other embodiments of the invention encompass pharmaceutical compositions comprising antibodies that bind to human TRAIN.
Claims11
An isolated antibody that specifically binds to a human TNF Receptor in the BRAIN (TRAIN) polypeptide comprising an amino acid sequence selected from the group consisting of:
- (a) SEQ ID NO:
- 3;
- (b) SEQ ID NO:
- 9;
- (c) amino acid residues 26 to 417 of SEQ ID NO:
- 3;
- (d) amino acid residues 1 to 173 of SEQ ID NO:
- 3;
- (e) amino acid residues 26 to 173 of SEQ ID NO:
- 3;
- (f) amino acid residues 174 to 190 of SEQ ID NO:
- 3;
- (g) amino acid residues 191 to 417 of SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.