Saspase knockout animal
AssigneeEisai R&D Management Co., Ltd.
InventorsTakeshi Matsui, Fumie Kisumi
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Abstract
Knockout animals in which a gene encoding a SASPase has been deleted (hereinafter, referred to as SASPase KO animals) are provided. The SASPase KO animals deficient in expression of functional SASPase were produced by deleting a gene encoding a stratified epithelium-specific protease, SASPase, through targeted disruption. The SASPase KO animals showed a significant increase in wrinkles on the sides of the body and so on. The SASPase KO animals find utility as animal models of wrinkles.
Claims3
A knockout mouse whose genome comprises a homozygous disruption in a stratified epithelium-specific protease (SASPase) gene, wherein the mouse has increased wrinkles as compared to a mouse whose genome comprises a heterozygous disruption in the SASPase gene.
Dependencies are inferred from the claim text.