Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)

A compound of formula (I)

• or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof, wherein
• R1 is selected from the group consisting of hydrogen, alkyl, haloalkyl, aryl, heteroaryl, heterocycle, cycloalkyl and cycloalkenyl;
• and R2 is —C(O)G;
• G is R4;
• R4 at each occurrence is independently selected from the group consisting of aryl, heteroaryl, cycloalkyl, cycloalkenyl, and heterocycle;
• wherein
• the aryl, heteroaryl, heterocycle, cycloalkyl, cycloalkenyl, and the heterocycle moiety of heterocyclealkyl, represented by R1, and R4, are each independently unsubstituted or substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of R7, alkyl, alkenyl, —CN, —NO2, halo, ethylenedioxy, methylenedioxy, oxo, —OR7A, —OC(O)R7A, —OC(O)OR7A, —OS(O)2R7A, —S(alkyl), —S(O)alkyl, —S(O)2R7A, —S(O)2OR7A, —S(O)2NR7ARb, —C(O)R7A, —C(O)OR7A, —C(O)NR7ARb, —NR7ARb, —NOR7A, —N(Rb)C(O)R7A, —N(Rb)C(O)OR7A, —N(Rb)S(O)2R7A, —N(Rb)C(O)NR7ARb, —N(Rb)S(O)2NR7ARb, haloalkyl, cyanoalkyl, nitroalkyl, -alkylenyl-OR7A, -alkylenyl-OC(O)R7A, -alkylenyl-OC(O)OR7A, -alkylenyl-OS(O)2R7A, -alkylenyl-S(alkyl), -alkylenyl-S(O)alkyl, -alkylenyl-S(O)2R7A, -alkylenyl-S(O)2OR7A, -alkylenyl-S(O)2NR7ARb, -alkylenyl-C(O)R7A, -alkylenyl-C(O)OR7A, -alkylenyl-C(O)NR7ARb, -alkylenyl-NR7ARb, -alkylenyl-NOR7A, -alkylenyl-N(Rb)C(O)R7A, -alkylenyl-N(Rb)C(O)OR7A, -alkylenyl-N(Rb)S(O)2R7A, -alkylenyl-N(Rb)C(O)NR7ARb, -alkylenyl-N(Rb)S(O)2NR7ARb and -alkylenyl-R7;
• R7A at each occurrence is independently selected from the group consisting of hydrogen, alkyl, alkenyl, haloalkyl, —R7 and -alkylenyl-R7;
• and
• R7 at each occurrence is independently selected from the group consisting of aryl, heteroaryl, cycloalkyl, cycloalkenyl and heterocycle;
• each R3 is independently selected from the group consisting of hydrogen, alkyl, and haloalkyl;
• is double bond;
• m is 4;
• Ar1 is a phenyl group;
• the phenyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, and heterocycle represented by Ar1 and R7, are independently unsubstituted or substituted with 1, 2, 3, 4 and 5 substituents independently selected from the group consisting of alkyl, alkenyl, —CN, —NO2, halo, ethylenedioxy, methylenedioxy, oxo, —ORa, —OC(O)alkyl, —OC(O)Oalkyl, —OS(O)2alkyl, —S(alkyl), —S(O)alkyl, —S(O)2alkyl, —S(O)2ORa, —S(O)2NRaRb, —C(O)Ra, —C(O)ORa, —C(O)NRaRb, —NRaRb, —NORa, —N(Rb)C(O)Ra, —N(Rb)C(O)ORa, —N(Rb)S(O)2Ra, —N(Rb)C(O)NRaRb, —N(Rb)S(O)2NRaRb, haloalkyl, cyanoalkyl, nitroalkyl, hydroxyalkyl, alkoxyalkyl, haloalkoxyalkyl, -alkylenyl-OC(O)alkyl, -alkylenyl-OC(O)Oalkyl, -alkylenyl-OS(O)2alkyl, -alkylenyl-S(alkyl), -alkylenyl-S(O)alkyl, -alkylenyl-S(O)2alkyl, -alkylenyl-S(O)2ORa, -alkylenyl-S(O)2NRaRb, -alkylenyl-C(O)Ra, -alkylenyl-C(O)ORa, -alkylenyl-C(O)NRaRb, -alkylenyl-NRaRb, -alkylenyl-NORa, -alkylenyl-N(Rb)C(O)Ra, -alkylenyl-N(Rb)C(O)ORa, -alkylenyl-N(Rb)S(O)2Ra, -alkylenyl-N(Rb)C(O)NRaRb, and -alkylenyl-N(Rb)S(O)2NRaRb;
• Ra at each occurrence is independently selected from the group consisting of hydrogen, alkyl, alkenyl and haloalkyl, and
• Rb at each occurrence is independently selected from the group consisting of hydrogen and alkyl.