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US 7,833,701 B2Granted
Biomolecule substrate, and test and diagnosis methods and apparatuses using the same
AssigneePanasonic Corporation
InventorMitsuaki Oshima
Life of this patent
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Abstract
An object of the present invention is to provide a test apparatus for testing a DNA substrate on which a plurality of DNA fragments for testing are arranged, wherein absolute precision is not required. The above-described problem was solved by providing a substrate on which a plurality of biomolecule spots containing a group of biomolecules (e.g., DNA, etc.) of a specific type are formed, where the pattern or position of the DNA spot is changed depending on specific data so that information of the specific data is recorded on the substrate.
Claims14
A method for fabricating a biomolecule substrate, comprising the steps of:
- 1) providing a set of biomolecules and a substrate;
- 2) preparing biomolecule microcapsules by i) producing, from a main solution, an emulsion comprising a medium and micro-emulsion particles containing an intended biomolecule from the set of biomolecules on the biomolecule-type-by-biomolecule-type basis and ii) producing a polymer thin film by interfacial polycondensation at an interface between the micro-emulsion particles and the medium so that the micro-emulsion particles are covered with the polymer thin film, thereby obtaining the biomolecule microcapsules;
- 3) dispersing the biomolecule microcapsules into a sub-solution;
- 4) spraying the sub-solution containing the biomolecule microcapsules onto the substrate;
- and 5) setting the temperature of the sub-solution containing the biomolecule microcapsules during spraying to be higher than the melting point of the polymer thin film.
2 more elements
Dependencies are inferred from the claim text.