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US 7,829,674 B2Granted
Compositions and methods for binding sphingosine-1-phosphate
AssigneeLpath, Inc.
InventorsRoger A. Sabbadini, William A. Garland, Genevieve Hansen, Steven Tarran Jones, David Gareth Williams
Life of this patent
Estimating the term…
Abstract
The present invention relates to anti-S1P agents, for example, humanized monoclonal antibodies, and their uses for detection of S1P or for treatment of diseases and conditions associated with S1P.
Claims6
An isolated antibody that binds sphingosine-1-phosphate (S1P) under physiological conditions and which comprises two light chain polypeptides and two heavy chain polypeptides, wherein:
- a. each light chain polypeptide comprises first, second, and third complementarity determining regions CDRL1, CDRL2, and CDRL3, respectively, wherein:
- (i) CDRL1 comprises amino acid sequence ITTTDIDDDMN (SEQ ID NO:
- 10);
- (ii) CDRL2 comprises amino acid sequence EGNILRP (SEQ ID NO:
- 11);
- and
- (iii) CDRL3 comprises amino acid sequence LQSDNLPFT (SEQ ID NO:
- 12);
- and
- b. each heavy chain polypeptide comprises first, second, and third complementarity determining regions CDRH1, CDRH2, and CDRH3, respectively, wherein:
- (i) CDRH1 comprises amino acid sequence DHTIH (SEQ ID NO:
- 13);
- (ii) CDRH2 comprises amino acid sequence AISPRHDITKYNEMFRG (SEQ ID NO:
- 31);
- and
- (iii) CDRH3 comprises amino acid sequence GGFYGSTIWFDF (SEQ ID NO:
- 15).
14 more elements
Dependencies are inferred from the claim text.