Antibodies against CD38 for treatment of multiple myeloma
AssigneeGenmab A/S
InventorsMichel De Weers, Yvo Graus, Judith Oprins, Paul Parren, Jan Van De Winkel, Martine Van Vugt
Life of this patent
Estimating the term…
Abstract
Isolated human monoclonal antibodies which bind to human CD38, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
Claims29
An isolated full-length antibody which binds to human CD38, wherein the antibody comprises a heavy chain variable region comprising the amino acid sequence set forth in SEQ ID NO:7 or encoded by the nucleotide sequence set forth in SEQ ID NO:6.
An isolated full-length antibody which binds to human CD38, wherein the antibody comprises a heavy chain variable region comprising the amino acid sequence set forth in SEQ ID NO:17 or encoded by the nucleotide sequence set forth in SEQ ID NO:16.
An isolated full-length antibody which binds to human CD38, wherein the antibody comprises a heavy chain variable region comprising the amino acid sequence set forth in SEQ ID NO:27 or encoded by the nucleotide sequence set forth in SEQ ID NO:26.
An isolated full-length antibody which binds to human CD38, wherein the antibody comprises a light chain variable region comprising the amino acid sequence set forth in SEQ ID NO:2 or encoded by the nucleotide sequence set forth in SEQ ID NO:
- 1.
An isolated full-length antibody which binds to human CD38, wherein the antibody comprises a light chain variable region comprising the amino acid sequence set forth in SEQ ID NO:
- 12 or encoded by the nucleotide sequence set forth in SEQ ID NO:
- 11.
An isolated full-length antibody which binds to human CD38, wherein the antibody comprises a light chain variable region comprising the amino acid sequence set forth in SEQ ID NO:22 or encoded by the nucleotide sequence set forth in SEQ ID NO:21.
An isolated full-length antibody which binds to human CD38, wherein the antibody comprises heavy and light chain variable region amino acid sequences as set forth in (a) SEQ ID NOs:7 and 2, respectively;
- (b) SEQ ID NOs:
- 17 and 12, respectively;
- or (c) SEQ ID NOs:
- 27 and 22, respectively.
An isolated full-length antibody which binds to human CD38, wherein the antibody comprises heavy and light chain variable regions encoded by the nucleotide sequence as set forth in (a) SEQ ID NOs:6 and 1, respectively;
- (b) SEQ ID NOs:
- 16 and 11, respectively;
- or (c) SEQ ID NOs:
- 26 and 21, respectively.
An isolated full-length antibody which binds to human CD38, wherein the antibody comprises a heavy chain variable region comprising CDR1, CDR2, and CDR3 sequences comprising the amino acid sequences set forth in SEQ ID NOs:
- 8, 9, and 10, respectively, and a light chain variable region comprising CDR1, CDR2, and CDR3 sequences comprising the amino acid sequences set forth in SEQ ID NOs:
- 3, 4, and 5, respectively.
An isolated full-length antibody which binds to human CD38, wherein the antibody comprises a heavy chain variable region comprising CDR1, CDR2, and CDR3 sequences comprising the amino acid sequences set forth in SEQ ID NOs:
- 18, 19, and 20, respectively, and a light chain variable region comprising CDR1, CDR2, and CDR3 sequences comprising the amino acid sequences set forth in SEQ ID NOs:
- 13, 14, and 15, respectively.
An isolated full-length antibody which binds to human CD38, wherein the antibody comprises a heavy chain variable region comprising CDR1, CDR2, and CDR3 sequences comprising the amino acid sequences set forth in SEQ ID NOs:
- 28, 29, and 30, respectively, and a light chain variable region comprising CDR1, CDR2, and CDR3 sequences comprising the amino acid sequences set forth in SEQ ID NOs:
- 23, 24, and 25, respectively.
Dependencies are inferred from the claim text.