Use of a PCV2 immunogenic composition for lessening clinical symptoms in pigs
AssigneeBoehringer Ingelheim Vetmedica GmbH
InventorsMichael Roof, Phillip Hayes, Marc Eichmeyer, Greg Nitzel, Merrill Schaeffer
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AssigneeBoehringer Ingelheim Vetmedica GmbH
InventorsMichael Roof, Phillip Hayes, Marc Eichmeyer, Greg Nitzel, Merrill Schaeffer
Estimating the term…
The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.
A method for reducing the immunosuppressive effect of porcine circovirus infection in pigs, comprising administering to a pig a single dose of an immunogenic composition containing 4 μg to 400 μug of recombinant PCV2 ORF2 protein and a polymer of acrylic or methacrylic acid, wherein the immunosuppressive effect is reduced in comparison to a pig not receiving an administration of said immunogenic composition.
Dependencies are inferred from the claim text.