Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography
AssigneeSiemens Medical Solutions USA, Inc.
InventorsRobert Michael Van Dam, Carroll Edward Ball, Arkadij M. Elizarov, Hartmuth C. Kolb
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Abstract
The present application relates to microfluidic devices and related technologies, and to chemical processes using such devices. More specifically, the application discloses a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner. In particular, this application describe an automated, stand-alone, microfluidic instrument for the multi-step chemical synthesis of radiopharmaceuticals, such as probes for PET and a method of using such instruments.
Claims45
A microfluidic system for synthesis of a radiolabeled compound, the system configured to transfer and facilitate the reaction of microliters and/or nanoliters of reagent, the system comprising:
- a microfluidic synthesis chip configured for conducting batch reactions, the chip comprising;
- a reaction chamber;
- an inlet flow channel in communication with the reaction chamber and configured to pass reagent into the reaction chamber, the inlet flow channel having a valve configured to regulate flow to the reaction chamber;
- and
- a plurality of outlet channels in communication with the reaction chamber and configured to pass reagent out of the reaction chamber, each channel having a valve configured to close to trap reagent within the reaction chamber during a reaction and release reagent and products when the reaction is complete;
- and
- a reagent source comprising at least one reagent, the reagent source in fluid communication with the reaction chamber via the at least one flow channel,
- wherein the reaction chamber has an area substantially greater than a cross-sectional area of each of the inlet flow channel and the outlet channels.
A portable microfluidic system for synthesis of a radiolabeled compound, the system configured to transfer and facilitate the reaction of microliters and/or nanoliters of reagent, the system comprising:
- a microfluidic synthesis chip configured to conduct batch reactions comprising:
- a reaction chamber;
- a vent in communication with the reaction chamber;
- at least one flow channel in communication with the reaction chamber;
- at least one valve configured to regulate flow to or from the reaction chamber;
- and
- a reagent source comprising at least one reagent in fluid communication with the reaction chamber via the flow channel;
- and
- a filter in communication with the reaction chamber and an area outside of the system, the filter configured to filter exhaust from the reaction chamber wherein the valve is configured to close to trap reagent within the reaction chamber during a reaction during a reaction and release reagent and products when the reaction is complete.
A microfluidic system for synthesis of a radiolabeled compound, the system configured to transfer and facilitate the reaction of microliters and/or nanoliters of reagent, the system comprising:
- a microfluidic synthesis chip configured to conduct batch reactions, the microfluidic synthesis chip comprising:
- a substrate comprising:
- a reaction chamber;
- an inlet channel in communication with the reaction chamber and configured to pass reagent into the reaction chamber, the inlet channel comprising a valve configured to regulate flow to the reaction chamber;
- an outlet channel in communication with the reaction chamber and configured to pass reagent out of the reaction chamber, the outlet channel having a valve configured to control reagent and product flow out of the reaction chamber;
- a gas permeable membrane in communication with the reaction chamber;
- a vent in communication with the reaction chamber;
- a reagent source in fluid communication with the reaction chamber via the inlet channel;
- and
- a gas source in communication with the at least one reagent such that gas conveys the reagent to the reaction chamber,
- wherein the valve of the outlet channel is configured to close to trap reagent within the reaction chamber during a reaction and release reagent and products when the reaction is complete.
Dependencies are inferred from the claim text.