Method of making self-supporting therapeutic active-containing film
AssigneeMonosol Rx, LLC
InventorsRobert K. Yang, Richard C. Fuisz, Garry L. Myers, Joseph M. Fuisz
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Abstract
The invention relates to film products containing desired levels of active components and methods of their preparation. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. Desirably, the films may be exposed to temperatures above that at which the active components typically degrade without concern for loss of the desired activity.
Claims191
A method of making a self-supporting therapeutic active-containing film comprising:
- (a) Mixing at least one edible polymer component, a therapeutic active composition, and at least one polar solvent to form a matrix;
- (b) Forming a wet film from said matrix;
- (c) Removing said polar solvent from said matrix with heat and/or radiation energy by exposing said matrix to a temperature greater than the degradation temperature of said therapeutic active composition;
- wherein the temperature of the matrix is 100° C. or less during said step of removing said polar solvent from said matrix.
A method of making a self-supporting therapeutic active-containing film comprising:
- (a) Mixing at least one edible polymer component, a therapeutic active composition, and at least one polar solvent to form a matrix;
- (b) Forming a wet film from said matrix;
- (c) Removing said polar solvent from said matrix with heat and/or radiation energy by heating said matrix to a temperature that is less than the boiling point of said at least one polar solvent so as to form a viscoelastic film.
A method of making a self-supporting therapeutic active-containing film comprising:
- (a) Mixing at least one edible polymer component, a therapeutic active composition, and at least one polar solvent to form a matrix;
- (b) Forming a wet film from said matrix;
- (c) Using heat and/or radiation energy to remove said polar solvent from said matrix to form a visco-elastic state without forming bubbles.
Dependencies are inferred from the claim text.