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US 7,820,871 B2Granted
Biological wound dressing and method of making
AssigneeGrandhope Biotech Co., Ltd.
InventorGuo-Feng Xu
Life of this patent
Estimating the term…
Abstract
A biological wound dressing is made by a method that includes the steps of providing a natural animal tissue that has a substrate, crosslinking and fixing the substrate, minimizing the antigens from the substrate, and incorporating an active layer in the substrate.
Claims21
A method for preparing a biological wound dressing, comprising:
- providing a substrate that is made from natural animal tissue;
- crosslinking and fixing the substrate with non-aldehyde fixatives;
- blocking residual specific active groups in protein molecules of the substrate after fixation by applying at least one active reagent;
- altering the specific conformation of protein molecules of the substrate by a reagent with strong hydrogen bonding power;
- and
- coupling an active layer to the substrate that includes either a polypeptide or a glucosaminoglycan that has the ability to adhere growth factors after implantation.
3 more elements
A biological wound dressing, comprising:
- a substrate that is made from natural animal tissue, the substrate having:
- (i) been fixed with crosslinking reagents, (ii) residual specific active groups in protein molecules of the substrate that have been blocked by at least one active reagent after fixation by the crosslinking reagents, (iii) specific conformation of protein molecules of the substrate altered by a reagent with strong hydrogen bonding power, and (iv) an active layer coupled thereto, the active layer including either a polypeptide or a glucosaminoglycan that has the ability to adhere growth factors after implantation.
A biological wound dressing made by a method comprising:
- providing a substrate that is made from a natural animal tissue;
- crosslinking and fixing the substrate with a non-aldehyde fixative;
- blocking residual specific active groups in protein molecules of the substrate after fixation by applying at least one active reagent;
- altering the specific conformation of protein molecules of the substrate by a reagent with strong hydrogen bonding power;
- and
- coupling an active layer to the substrate that includes either a polypeptide or a glucosaminoglycan that has the ability to adhere growth factors after implantation.
3 more elements
Dependencies are inferred from the claim text.