Back to results
US 7,820,798 B2Granted
Tumor necrosis factor-gamma
AssigneeHuman Genome Sciences, Inc.
InventorsGuo-Liang Yu, Jian Ni, Craig A. Rosen, Jun Zhang
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeHuman Genome Sciences, Inc.
InventorsGuo-Liang Yu, Jian Ni, Craig A. Rosen, Jun Zhang
Estimating the term…
Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
An isolated antibody or fragment thereof that specifically binds to a protein selected from the group consisting of:
An isolated antibody or fragment thereof that specifically binds a tumor necrosis factor-gamma protein purified from a cell culture wherein said tumor necrosis factor-gamma protein is encoded by a polynucleotide encoding amino acids 1 to 251 of SEQ ID NO:20;
Dependencies are inferred from the claim text.