Cinnamic, phenylpropiolic and phenylpropanoic acid derivatives useful as anti-tumor agents

A compound of the following formula I:

• wherein:
• n is 0;
• A is a monovalent group and is selected from the group consisting of:
• NH—OG and, the group
• where G and G′ are H,
• Y is a group selected among HC═CH, CH2—CH2 and C≡C;
• R is the group:
• where X is either O, NH;
• or
• R is the group:
• Z is H;
• R1 is H;
• or:
• R and R1, taken together with the aromatic group, form a polycyclic group having the following formula:
• R2 is selected from the group consisting of:
• H;
• (C6-C12) aryl or (C6-C12) aryl substituted with nitro, halogen, (C1-C4) alkoxycarbonyl;
• (C1-C4) alkyl, (C2-C4) alkenyl;
• (C6-C12) aryl-(CH2)n″, where aryl is substituted with nitro halogen, (C1-C4) alkoxycarbonyl, where n″=0-3;
• (C6-C12) aryl-CO, where aryl is substituted with halogen (C1-C4);
• and
• (C6) heterocyclyl-(C1-C3) alkylene where at least one of the CH2 of the heterocycle is substituted by O;
• R3 is H;
• R4 is H;
• R5 is H;
• its tautomers, geometrical isomers, optically active forms as enantiomers, diastereomers and racemate forms, as well as its pharmaceutically acceptable salts.