Antisense modulation of hydroxysteroid 11-beta dehydrogenase 1 expression
AssigneeIsis Pharmaceuticals, Inc.
InventorSusan M. Freier
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of hydroxysteroid 11-beta dehydrogenase 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding hydroxysteroid 11-beta dehydrogenase 1. Methods of using these compounds for modulation of hydroxysteroid 11-beta dehydrogenase 1 expression and for treatment of diseases associated with expression of hydroxysteroid 11-beta dehydrogenase 1 are provided.
Claims23
A compound comprising a modified oligonucleotide consisting of 12 to 30 linked nucleosides and having a nucleobase sequence comprising a portion having at least 8 contiguous nucleobases complementary within nucleotides 771-841 of SEQ ID NO:
- 3 and wherein said compound inhibits the expression of hydroxysteroid 11-beta dehydrogenase 1.
A compound 12 to 30 nucleobases in length which specifically hybridizes with at least an 8-nucleobase portion within nucleotides 771-841 of SEQ ID NO:3 encoding hydroxysteroid 11-beta dehydrogenase 1.
Dependencies are inferred from the claim text.