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AssigneeIndian Immunologicals Limited
InventorsHema Masarapu, Singanallur Balasubramanian Nagendrakumar, Dorairajan Thiagarajan, Villuppanoor Alwar Srinivasan
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The present disclosure relates to chimeric tymovirus-like particles (TVLPs) comprising a fusion protein that further comprises of a first protein that is a truncated tymovirus coat protein and a second protein. These chimeric TVLPs are useful as antigens. The present disclosure provides a highly efficient means for differentiating Foot and Mouth Disease Virus (FMDV) infected animals from vaccinated animals. The present disclosure further provides a process for the production of chimeric TVLPs and a diagnostic kit for the determination of specific antibodies of FMDV to differentiate FMDV infected from vaccinated animals. The present disclosure also provides the use of the chimeric TVLPs for diagnostic purposes.
A chimeric tymovirus-like particle comprising a fusion protein, wherein the fusion protein comprises a first protein of tymovirus Physalis mottle virus (PhMV) coat protein and a second protein, wherein the second protein is Foot and Mouth Disease Virus (FMDV) protein, wherein the first protein comprises at least the 149 contiguous amino acids of the C-terminus of the amino acid sequence as shown in SEQ ID NO:
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