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US 7,811,757 B2Granted
Methods for disease detection
AssigneeGenzyme Corporation
InventorAnthony P. Shuber
Life of this patent
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Abstract
The present invention provides methods for detecting disease by analysis of a patient sample to determine the integrity of nucleic acids in the sample.
Claims12
A method of detecting fetal abnormality, the method comprising the steps of:
- conducting a plurality of amplification reactions on a nucleic acid to produce a plurality of nucleic acid fragments of different lengths, wherein the nucleic acid is obtained from maternal blood comprising fetal cells or fetal cellular debris;
- qualitatively determining amplification level in the plurality of amplification reactions;
- and
- identifying fetal abnormality if the qualitative amplification level is greater than a pre-determined threshold level.
1 more element
Dependencies are inferred from the claim text.