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AssigneeGE Healthcare Bio-Sciences AB
InventorsMagnus Malmqvist, Hakan Roos, Stefan Sjolander, Mattias Tidare, Hakan Sjodin, Ralph Stalberg
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Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.
A sensor device comprising a flow cell having an inlet end and an outlet end, at least one sensing surface on a wall surface within the flow cell located between the inlet and outlet ends, wherein the flow cell has N inlet openings at the inlet end where N=2 or 3, and at least one outlet opening at the outlet end, such that separate laminar fluid flows entering the flow cell through the respective inlet openings can flow side by side through the flow cell over the sensing surface, and wherein the sensing surface has at least N+1 discrete sensing areas thereon located at different lateral positions with respect to the fluid flow direction.
Dependencies are inferred from the claim text.