US 7,811,463 B2 · Centrifuge apparatus and methods for on-line harvesting of a predetermined component of a fluid medium

Abstract

A rotatable rotor for separating components contained in a fluid, comprising an annular base having a first annular channel and an annular cover having a second annular channel for holding a flexible doughnut-shaped centrifuge bag therebetween. The cover has one or more radially spaced apart concentric indicator lines for monitoring the separation of the components. When the base and cover are superimposed, the first and second channels define an annular interior chamber having an off-centered figure eight configuration. The base and cover each comprise a grooved column axially centered and extending from the base top surface and the cover bottom surface, respectively. The flexible bag comprises inner and outer tubes extending from the core of the bag and which are seated in the column grooves to ensure that the bag is fixably rotatable with the rotor.

Claims13

Dependent claims

A centrifuge apparatus for on-line harvesting of a predetermined component of a fluid medium, comprising:

a disposable centrifuge bag for containing the fluid medium during separation further comprising at least one inlet and at least one outlet tube;
a rotor having an annular base with a first annular channel and an annular cover having a second annular channel for holding the centrifuge bag therebetween;
an inlet lumen fluidly connected to at least one inlet tube of the centrifuge bag and an outlet lumen fluidly connected to at least one outlet tube of the centrifuge bag;
wherein a fluid medium is provided to the centrifuge bag via the inlet lumen of the tubing during the rotation of the centrifuge and a harvested predetermined component may be removed from the centrifuge bag via the outlet lumen during the continued rotation of the centrifuge;
wherein the centrifuge bag is a rigid and transparent bag having an interior chamber having an off-centered, figure eight cross-sectional configuration.

2 more elements

A method for on-line harvesting of a predetermined component of a fluid medium, comprising:

providing a disposable centrifuge bag for containing the fluid medium during separation further comprising
at least one inlet and at least one outlet tube;
a rotatable rotor having an annular base with a first annular channel and an annular cover having a second annular channel for holding the centrifuge bag therebetween;
an inlet lumen fluidly connected to at least one inlet tube of the centrifuge bag and an outlet lumen fluidly connected to at least one outlet tube of the centrifuge bag;
providing a fluid medium to the centrifuge bag via the inlet lumen of the tubing during the rotation of the centrifuge and removing a harvested predetermined component from the centrifuge bag via the outlet lumen during the continued rotation of the centrifuge;
rotating the said centrifuge rotor;
providing the desired degree of separation and removing the harvested predetermined fraction from the said centrifuge bag via the outlet lumen during continued rotation of the centrifuge;
wherein the centrifuge bag is a rigid and transparent bag having an interior chamber having an off-centered, figure eight cross-sectional configuration.

5 more elements

Dependencies are inferred from the claim text.

Centrifuge apparatus and methods for on-line harvesting of a predetermined component of a fluid medium

Life of this patent

Centrifuge apparatus and methods for on-line harvesting of a predetermined component of a fluid medium

Life of this patent

Abstract

Claims13