Procedure for preparing 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazineyl)-dibenzo[b,f] [1,4]thiazepine
AssigneeInke, S.A.
InventorsSalvador Puig Torres, Reyes Herbera Espinal, Pere Dalmases Barjoan
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Abstract
The invention relates to a procedure for preparing quetiapine by reaction between a compound of formula (II) and a compound of formula (III), in which X means a leaving group and P a protective group of alcohols resistant to alkaline conditions, in the presence of a base, followed by a step of deprotection and, optionally, obtaining a pharmaceutically acceptable salt thereof. Said procedure permits the obtaining of quetiapine with a high degree of purity under soft temperature conditions, with short reaction times and avoiding the use of toxic solvents. (Graphic)
Claims17
Procedure for obtaining 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl)-dibenzo[b,f] [1,4]thiazepine, of formula (I)
- or a pharmaceutically acceptable salt thereof, wherein it comprises reaction between compound of formula (II) and a compound of formula (III):
- in which X means a leaving group and P a protective group of alcohols resistant to alkaline conditions, in the presence of a base, followed by a step of deprotection and, eventually, obtaining a pharmaceutically acceptable salt thereof.
Intermediate of formula (IV):
- in which P is a protective group of alcohols resistant to alkaline conditions.
Dependencies are inferred from the claim text.