Methods and reagents for treating glucose metabolic disorders

A method for treating a disease associated with altered glucose metabolism, comprising administering to an animal having a disease associated with altered glucose metabolism a composition comprising an amount of a PYY peptidomimetic effective to treat said disease associated with altered glucose metabolism, wherein said PYY peptidomimetic comprises a peptide with at least 80% amino acid identity to SEQ ID No. 2, and wherein said PYY peptidomimetic binds a PYY receptor and promotes glucose responsiveness.

A method for maintaining or restoring normal pancreatic cell function in an animal having impaired pancreatic cell function, wherein the function is glucose responsivity or glucose sensing, comprising administering to said animal an amount of a PYY peptidomimetic, wherein said PYY peptidomimetic comprises a peptide having the amino acid sequence of SEQ ID NO:

• 2, wherein the amount of said PYY peptidomimetic is sufficient to maintain or restore normal pancreatic cell function, and wherein the PYY peptidomimetic binds a PYY receptor and promotes glucose-responsiveness of said pancreatic cell.

A method for maintaining or restoring normal pancreatic cell function to an animal having impaired pancreatic cell function, wherein the function is glucose responsivity or glucose sensing, comprising administering to said animal an amount of a PYY peptidomimetic, wherein said PYY peptidomimetic comprises a peptide with at least 80% amino acid identity to SEQ ID No. 2, wherein the amount of said PYY peptidomimetic is sufficient to maintain or restore normal pancreatic cell function to said animal, and wherein said PYY peptidomimetic binds a PYY receptor and promotes glucose-responsiveness of said pancreatic cell.

A method for maintaining or restoring a function of a pancreatic β cell in an animal having impaired β cell function, wherein the function is glucose responsivity or glucose sensing, comprising administering to said animal a composition comprising an amount of a PYY peptidomimetic, wherein said PYY peptidomimetic comprises a peptide with at least 80% amino acid identity to SEQ ID NO:

• 2, wherein the amount of said PYY peptidomimetic is sufficient to maintain or restore the function of said pancreatic β cell, and wherein the PYY peptidomimetic binds a PYY receptor and promotes glucose-responsiveness of said pancreatic cell.

A method for promoting a gain of glucose responsivity in pancreatic β cells in an animal having a metabolic disorder, comprising administering to said animal a composition including a PYY peptidomimetic in an amount effective to promote a gain of glucose responsivity, wherein said PYY peptidomimetic comprises a peptide with at least 80% amino acid identity to SEQ ID No. 2, and wherein the PYY peptidomimetic binds a PYY receptor and promotes glucose-responsiveness.

A method for inducing or enhancing the glucose-responsiveness of a pancreatic cell in an animal having a metabolic disorder, which pancreatic cell has impaired glucose-responsiveness, comprising administering to said animal an amount of a PYY peptidomimetic, wherein said PYY peptidomimetic comprises a peptide with at least 80% amino acid identity to SEQ ID No. 2, wherein the amount of said PYY peptidomimetic is sufficient to induce or enhance the glucose-responsiveness of said pancreatic cell, and wherein the PYY peptidomimetic binds a PYY receptor and promotes glucose-responsiveness of said pancreatic cell.

A method for inducing or enhancing glucose metabolism in an animal having a disease associated with abnormal glucose metabolism, comprising administering to said animal a composition including an amount of a PYY peptidomimetic, wherein said PYY peptidomimetic comprises a peptide with at least 80% amino acid identity to SEQ ID No. 2, wherein the amount of PYY peptidomimetic is effective to induce or enhance glucose responsiveness in said animal, thereby inducing or enhancing glucose metabolism in said animal, and wherein the PYY peptidomimetic binds a PYY receptor and promotes glucose responsiveness.

A method for inducing, enhancing, or maintaining glucose-responsiveness of a pancreatic cell in an animal having a metabolic disorder, which pancreatic cell has impaired glucose-responsiveness, comprising administering to said animal a composition comprising an amount of a PYY peptidomimetic, wherein the amount of said PYY peptidomimetic is sufficient to induce, enhance, or maintain the glucose-responsiveness of said pancreatic cell, wherein said PYY peptidomimetic comprises a peptide with at least 80% amino acid identity to SEQ ID No. 2, and wherein said PYY peptidomimetic binds a PYY receptor and promotes glucose-responsiveness of said pancreatic cell.