US 7,807,149 B2 · Bacteriophage-containing therapeutic agents

Abstract

The present invention relates in its broadest aspect to combined phage/antibiotic therapy. More particularly, it relates to use of (i) one or more bacteriophages and (ii) one or more antibiotics in the manufacture of a combined product for simultaneous, separate or sequential administration of (i) and (ii) to treat a bacterial infection characterized by biofilm formation, for example an infection comprising or consisting of P. aeruginosa. Treatment in this context may be either therapeutic or prophylactic treatment. Also provided are deposited bacteriophages each exhibiting different strain specificity against P. aeruginosa and combinations of such bacteriophages, e.g. a panel of six deposited bacteriophages which was found to be effective against a high percentage of clinical isolates of P. aeruginosa from canine ear infections.

Claims7

Dependent claims

A method of treatment of a bacterial infection characterized by biofilm formation, wherein said bacterial infection comprises Pseudomonas aeruginosa, and wherein said method comprises:

(a) administering to a human or non-human animal in need thereof one or more bacteriophage preparations comprising bacteriophages NCIMB 41174, NCIMB 41175, NCIMB 41176, NCIMB 41177, NCIMB 41178 and NCIMB 41179, wherein said bacteriophages target and kill said Pseudomonas aeruginosa present in the biofilm;
and
(b) sequentially administering one or more antibiotics active against a bacterial species present in the biofilm, wherein said one or more antibiotics is administered after the bacteriophages have commenced replication in a targeted Pseudomonas aeruginosa present in the biofilm.

Dependencies are inferred from the claim text.

Bacteriophage-containing therapeutic agents

Life of this patent

Bacteriophage-containing therapeutic agents

Life of this patent

Abstract

Claims7