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US 7,804,299 B2Granted
Diffusion weighted preparatory sequence for magnetic resonance imaging pulse sequence
AssigneeWisconsin Alumni Research Foundation
InventorsScott B. Reeder, Reed Busse, Jean H. Brittain
Life of this patent
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Abstract
A preparatory pulse sequence is applied prior to an imaging pulse sequence during a diffusion-weighted MRI scan. The preparatory pulse sequence diffusion weights the longitudinal magnetization using a gradient waveform that is first moment nulled to reduce image artifacts caused by patient motion.
Claims3
A method for producing a diffusion-weighted image with a magnetic resonance imaging (MRI) system, the steps comprising:
- a) performing a preparation pulse sequence with the MRI system that diffusion weights longitudinal magnetization in a subject, the preparation pulse sequence including:
- a)i) applying a radio frequency (RF) excitation pulse to produce transverse spin magnetization;
- a)ii) applying a first moment nulled diffusion weighting gradient waveform to diffusion weight the transverse spin magnetization;
- a)iii) applying an RF excitation pulse to produce diffusion-weighted longitudinal spin magnetization from the diffusion weighted transverse magnetization;
- and
- a)iv) applying an RF refocusing pulse such that the diffusion weighted transverse magnetization is refocused when the RF excitation pulse is produced in step a)iii);
- b) performing an imaging pulse sequence following step a);
- c) repeating steps a) and b) as necessary to acquire a set of data from which an image can be reconstructed;
- and
- d) reconstructing a diffusion-weighted image from the acquired set of data.
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