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US 7,803,966 B2Granted
Cosmetic and pharmaceutical compositions comprising compounds that display retinoid like activities
AssigneeJohnson & Johnson Consumer France SAS
InventorsThierry Oddos, Otto von Stetten, Luc van Hijfte
Life of this patent
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Abstract
This invention relates to novel compounds that display retinoid like activities, including HB-EGF (Heparin Binding Epidermal Growth Factor) release from keratinocytes, cell proliferation, and epidermal thickening without the irritation potentials, such as release of interleukin 8 and inhibition of terminal differentiation of keratinocytes. This invention also relates to the use of such a compound for both external and non-external applications.
Claims11
A compound of Formula (I)
- wherein
- R1 is COOR10;
- Z is selected from a bond, and O—C1-4alkyl;
- R2 is hydrogen;
- R3 is hydroxyl;
- X is selected from the group consisting of —CH═CH— and —N═N—;
- R4 is selected from the group consisting of hydroxy and —NR15R16;
- R5 is selected from the group consisting of hydrogen and —NR15R16;
- R6 is hydrogen;
- R7 is hydrogen;
- R8 is selected from the group consisting of hydrogen, and halo;
- R9 is selected hydroxy;
- R10 is hydrogen;
- R15 and R16 are each independently hydrogen;
- or
- a pharmaceutically acceptable or a cosmetically acceptable salt thereof.
13 more elements
A compound selected from the group consisting of
A compound of the formula
- wherein
- R1 is COOH;
- Z is oxygen;
- R2, R3, R4, R5, R6, R7, R8 and R9 are each independently H;
- and
- X is —CH═CH—;
- or
- a pharmaceutically acceptable or a cosmetically acceptable salt thereof.
5 more elements
Dependencies are inferred from the claim text.