Process for the resolution of racemic verapamil
AssigneeCosma S.p.A.
InventorsChiara Bertolotti, Massimiliano Lussana, Enrica Pizzatti, Enrico Vigano', Ernesto Landonio
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Abstract
A new process is described for the resolution of racemic verapamil, which allows the desired enantiomer to be obtained in high yields and with high enantiomeric purity. The process uses optically active 2,3-bis[(2-fluorobenzoyl)oxy]butanedioic acid as the resolving agent, and a water/dimethylformamide or water/acetonitrile or water/methanol mixture, as the reaction solvent.
Claims11
A process for the enantiomeric resolution of verapamil, characterized in that racemic verapamil is reacted with one of the two optical antipodes of 2,3-bis[(2-fluorobenzoyl)oxy]butanedioic acid, in the presence of a solvent.
Dependencies are inferred from the claim text.