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US 7,803,946 B2Granted
Tunable phenylacetylene hosts
OwnerMichael M. Haley, Darren W. Johnson +3inventors
InventorsMichael M. Haley, Darren W. Johnson, Orion B. Berryman, Charles A. Johnson, Calden N. Stimpson
Life of this patent
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Abstract
Disclosed herein is a class of tunable phenylacetylene compounds as well as compositions and methods for their use as host compounds for ligand binding. In certain examples the hosts report binding events by exhibiting altered spectroscopic properties, such as different fluorescent emission spectra.
Claims7
A compound or salt thereof comprising the formula
- wherein Y is
- n is 1 or 2;
- R is H or lower alkyl;
- R1 is H, lower alkyl or aralkyl;
- R2 is selected from H, acyl, aralkyl, phosphonyl, —SO2R3;
- —(R4)C(O)R5;
- —N(R6)C(O)OR7, and —N(R8)C(O)NR9R10;
- and
- R3;
- R4;
- R5;
- R6;
- R7;
- R8;
- R9 and R10 independently are selected from H, lower alkyl, aralkyl, and aryl.
12 more elements
A compound or salt thereof comprising the formula
- wherein Y is a pyridine or bipyridine;
- R is selected from H and lower alkyl;
- and
- X is selected from —N(H)SO2R3;
- —N(R4)C(O)R5;
- —N(R6)C(O)OR7;
- and —N(R8)C(O)NR9R10;
- R3;
- R4;
- R5;
- R6;
- R7;
- R8;
- R9;
- and R10 independently are selected from H, lower alkyl, aralkyl, and aryl.
12 more elements
A compound or salt thereof comprising the formula
- wherein Y is a pyridine or bipyridine:
- X is selected from —N(H)SO2R3;
- —N(R4)C(O)R5;
- —N(R6)C(O)OR7;
- and —N(R8)C(O)NR9R10;
- and
- R3;
- R4;
- R5;
- R6;
- R7;
- R8 R9 and R10 independently are selected from H, lower alkyl, aralkyl, and aryl.
9 more elements
A compound or salt thereof comprising the formula
- wherein Y is a pyridine or bipyridine:
- R is lower alkyl;
- X is halogen, —OR11, alkyl sulfide, nitro, sulfonyl, phosphonyl, phosphate, sulfate, or lower alkyl;
- and R11 is H, acyl, or optionally substituted lower alkyl.
1 more element
Dependencies are inferred from the claim text.