Identification of novel broadly cross-reactive neutralizing human monoclonal antibodies using sequential antigen panning of phage display libraries
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsDimiter S Dimitrov, Mei-Yun Zhang
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Abstract
The present invention provides a method of identifying novel broadly crossreactive neutralizing monoclonal antibodies using sequential antigen panning of phage display libraries, antibodies obtained in accordance with such a method, as well as fusion proteins and conjugates comprising same, and related isolated or purified nucleic acid molecules, vectors, host cells, compositions, and methods of use to inhibit an infection, reduce the severity of an infection, treat an infection, and inhibit cancer.
Claims20
An isolated antibody or antibody fragment to HIV envelope glycoprotein that can recognize one or more strains of HIV, wherein the antibody or antibody fragment comprises the sequence of SEQ ID NO:
- 1 or a variant thereof, wherein the variant comprises the sequence of SEQ ID NO:
- 13 as complementarity determining region 3 (CDR3), and retains the ability to bind to the same epitope on HIV envelope glycoprotein as that of the sequence of SEQ ID NO:
- 1.
An isolated antibody or antibody fragment to HIV envelope glycoprotein that can recognize one or more strains of HIV, wherein the antibody or antibody fragment comprises the sequence of SEQ ID NO:
- 1, the sequence of SEQ ID NO:
- 6, or both the sequence of SEQ ID NO:
- 1 and the sequence of SEQ ID NO:
- 6.
Dependencies are inferred from the claim text.