Mucosal vascular addressing and uses thereof

A fusion protein comprising an α4β7 integrin-binding fragment of a naturally occurring primate MAdCAM, wherein said primate MAdCAM has at least about 75% amino acid sequence similarity to an amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:4 and SEQ ID NO:6, and said α4β7 integrin-binding fragment comprises the N-terminal immunoglobulin-like domain of said primate MAdCAM.

A fusion protein comprising a naturally occurring human MAdCAM, wherein said naturally occurring human MAdCAM binds α4β7 integrin and has at least about 75% amino acid sequence similarity to SEQ ID NO:2 or SEQ ID NO:4.

A fusion protein comprising an α4β7 integrin-binding fragment of a naturally occurring human MAdCAM, wherein said naturally occurring human MAdCAM binds α4β7 integrin and has at least about 75% amino acid sequence similarity to SEQ ID NO:2 or SEQ ID NO:4, and said α4β7 integrin-binding fragment comprises the two N-terminal immunoglobulin-like domains of said human MAdCAM.

A fusion protein comprising a primate MAdCAM moiety, wherein said primate MAdCAM moiety has binding affinity for α4β7 integrin and comprises an amino acid sequence selected from the group consisting of SEQ ID NO:2 and the amino acid sequence of an α4β7 integrin-binding portion of the polypeptide shown in FIG. 1 (SEQ ID NO:2), wherein said α4β7 integrin-binding portion comprises the N-terminal immunoglobulin-like domain.

A fusion protein comprising a primate MAdCAM moiety, wherein said primate MAdCAM moiety has binding affinity for α4β7 integrin and comprises an amino acid sequence selected from the group consisting of SEQ ID NO:4 and the amino acid sequence of an α4β7 integrin-binding portion of the polypeptide shown in FIG. 2 (SEQ ID NO:4), wherein said α4β7 integrin-binding portion comprises the N-terminal immunoglobulin-like domain.

A fusion protein comprising a naturally occurring primate MAdCAM, wherein said naturally occurring primate MAdCAM binds α4β7 integrin and has at least about 90% amino acid sequence similarity to an amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:4 and SEQ ID NO:6.

A fusion protein comprising an α4β7 integrin-binding fragment of a naturally occurring primate MAdCAM, wherein said naturally occurring primate MAdCAM has at least about 90% amino acid sequence similarity to SEQ ID NO:2, SEQ ID NO:4 or SEQ ID NO:6, and said α4β7 integrin-binding fragment comprises at least one immunoglobulin-like domain of said primate MAdCAM.

A fusion protein comprising a naturally occurring human MAdCAM, wherein said naturally occurring human MAdCAM binds α4β7 integrin and has at least about 90% amino acid sequence similarity to SEQ ID NO:2 or SEQ ID NO:4.

A fusion protein comprising an α4β7 integrin-binding fragment of a naturally occurring human MAdCAM, wherein said naturally occurring human MAdCAM binds α4β7 integrin and has at least about 90% amino acid sequence similarity to SEQ ID NO:2 or SEQ ID NO:4, and said α4β7 integrin-binding fragment comprises the two N-terminal immunoglobulin-like domains of said human MAdCAM.

A fusion protein comprising a primate MAdCAM or α4β7 integrin-binding fragment thereof, wherein said primate MAdCAM binds α4β7 integrin and has at least about 90% amino acid sequence similarity to an amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:4, and said α4β7 integrin-binding fragment comprises at lease one immunoglobulin-like domain of said primate MAdCAM.