Polypeptides with natriuresis activity
AssigneeMayo Foundation for Medical Education and Research
InventorsJohn C. Burnett, Jr., Timothy M. Olson
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Abstract
This document provides methods and material related to natriuretic polypeptides. For example, substantially pure polypeptides having a natriuretic peptide activity, nucleic acids encoding polypeptides having a natriuretic peptide activity, host cells containing such nucleic acids, and methods for inducing a natriuretic or diuretic activity within a mammal are provided.
Claims9
A substantially pure polypeptide comprising a first amino acid sequence and a second amino acid sequence, wherein said first amino acid sequence comprises the sequence of a natriuretic polypeptide having natriuresis activity, wherein said second amino acid sequence comprises the amino acid sequence as set forth in SEQ ID NO:1 or the amino acid sequence as set forth in SEQ ID NO:1 having less than five amino acid additions, subtractions, and substitutions, wherein said substantially pure polypeptide has said natriuresis activity.
Dependencies are inferred from the claim text.