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US 7,803,841 B2Granted
EP2 receptor agonists
AssigneeAsterand UK Limited
InventorsAlexander William Oxford, Richard Jon Davis, Robert Alexander Coleman, Kenneth Lyle Clark, David Edward Clark, Neil Victor Harris, Garry Fenton, George Hynd, Keith Alfred James Stuttle, Jonathan Mark Sutton, Mark Richard Ashton, Edward Andrew Boyd, Shirley Ann Brunton
Life of this patent
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Abstract
The disclosure provides EP2 receptor agonist compounds and methods for using the compounds for treating conditions which can be alleviated by agonism of an EP2 receptor.
Claims13
A compound of formula (I):
- or a salt thereof, wherein:
- R5 is an optionally substituted phenyl group where the substituents are selected from the group consisting of:
- unsubstituted C1-4 alkyl, C1-4 alkoxy, —CF3, halo, acyl, amino, and alkoxylene;
- where Q is CH;
- R3 is selected from the group consisting of H, F, Cl, optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl and C5-7 aryl-C1-4 alkyl groups;
- R4 is selected from the group consisting of H, F, Cl, optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl, and C5-7 aryl-C1-4 alkyl groups;
- R6 is selected from the group consisting of H, F, Cl, optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl, and C5-7 aryl-C1-4 alkyl groups;
- D is selected from the group consisting of
- B is selected from the group consisting of
- where one of RP3 and RP4 is —Cm alkylene-R2 and the other of RP3 and RP4 is H, m and n are independently 0 or 1, and m+n=1 or 2;
- and additionally when RP3 is —Cm alkylene-R2, m is 2 or 3, and m+n=2, 3 or 4, and when R2 is tetrazol-5-yl, m+n is 0;
- or
- where one of RP3 and RP4 is —O—CH2—R2, and the other of RP3 and RP4 is H, n is 0;
- RN is H or optionally substituted C1-4 alkyl;
- R2 is either:
- (i) —CO2H (carboxy);
- (ii) —CONH2;
- (iii) —CH2—OH (methoxy);
- or
- (iv) tetrazol-5-yl.
17 more elements
A compound which is:
- {3-[(4-Chloro-biphenyl-3-carbonyl)-amino]-phenyl}-acetic acid;
- {3-[(6-Fluoro-biphenyl-3-carbonyl)-amino]-phenyl}-acetic acid;
- {3-[(Biphenyl-3-carbonyl)-amino]-phenyl}-acetic acid;
- {3-[(4-Fluoro-biphenyl-3-carbonyl)-amino]-phenyl}-acetic acid;
- {3-[(5-Fluoro-biphenyl-3-carbonyl)-amino]-phenyl}-acetic acid;
- 3-{3-[(4-Fluoro-biphenyl-3-carbonyl)-amino]-phenyl}-acrylic acid;
- 3-{3-[(4,3′-Difluoro-biphenyl-3-carbonyl)-amino]-phenyl}-acrylic acid;
- {3-[(4,3′-Difluoro-biphenyl -3-carbonyl )-amino]-phenyl}-acetic acid;
- 3-{3- [(4,4′-Difluoro-biphenyl-3-carbonyl)-amino]-phenyl }acrylic acid;
- [3-(Biphenyl-3-ylcarbamoyl)-phenyl]-acetic acid;
- {3-[(3′-Chloro-4-fluoro-biphenyl-3-carbonyl)-amino]-phenoxy}-acetic acid;
- 3-{3-[(3′-Chloro-4-fluoro-biphenyl-3 -carbonyl)-amino]-phenyl}-acrylic acid;
- {3-[(3′,5′-Dichloro-4-fluoro-biphenyl-3-carbonyl) -amino]-phenoxy}-acetic acid;
- 3-{3 -[(3′, 5′-Dichloro-4-fluoro-biphenyl-3-carbonyl)-amino]-phenyl}-acrylic acid;
- {3-[(4-Fluoro-biphenyl-3-carbonyl)-amino]-phenoxy}-acetic acid;
- {3-[(4,3′-Difluoro-biphenyl-3-carbonyl)-amino]-phenoxy}-acetic acid;
- {3-[(4,4′-Difluoro-biphenyl-3-carbonyl)-amino]-phenoxy}-acetic acid;
- or
- 4-Fluoro-biphenyl-3-carboxylic acid {3-[2-(lH-tetrazol-5yl)-vinyl]phenyl}-amide.
16 more elements
Dependencies are inferred from the claim text.