4-oxo-4,5-dihydro-furan-2-carboxylic acid derivatives and methods of treatment of metabolic-related disorders thereof

A compound of Formula (I):

• or a pharmaceutically acceptable salt, hydrate or solvate thereof,
• wherein:
• R1 is H or C1-6 alkyl;
• R2 is H, halogen, C1-4 alkyl or C1-4 haloalkyl;
• and
• R3 is heteroaryl, which is optionally substituted with 1 to 4 substituents independently selected from the group consisting of C1-6 acyloxy, C2-6 alkenyl, C1-6 alkoxy, C1-6 alkyl, C1-6 alkylcarboxamide, C2-6 alkynyl, C1-6 alkylsulfonamide, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, C1-6 alkylthio, C1-6 alkylureyl, C1-6 alkylamino, amino, aryl, substituted aryl, carbo-C1-6-alkoxy, carboxamide, cyano, C3-7 cycloalkyl, C2-6 dialkylamino, C2-6 dialkylcarboxamide, C2-6 dialkylsulfonamide, halogen, C1-6 haloalkoxy, C1-6 haloalkyl, C1-6 haloalkylsulfinyl, C1-6 haloalkylsulfonyl, C1-6 haloalkylthio, heteroaryl, substituted heteroaryl, hydroxyl, nitro and thiol;
• and
• R4 is selected from the group consisting of H, C1-6 alkyl C3-6- cycloalkyl and C1-6 haloalkyl wherein each are optionally substituted with 1 to 5 substituents independently selected from the group consisting of C1-6 acyloxy, C2-6 alkenyl, C1-6 alkoxy, C1-6 alkylcarboxamide, C2-6 alkynyl, C1-6 alkylsulfonamide, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, C1-6 alkylthio, C1-6 alkylureyl, C1-6 alkylamino, amino, carbo-C1-6-alkoxy, carboxamide, cyano, C3-7 cycloalkyl, C2-6 dialkylamino, C2-6 dialkylcarboxamide, C2-6 dialkylsulfonamide, halogen, C1-6 haloalkoxy, C1-6 haloalkyl, C1-6 haloalkylsulfinyl, C1-6 haloalkylsulfonyl, C1-6 haloalkylthio, hydroxyl, nitro and thiol.