Aminophenylsulfonamide derivatives as HIV protease inhibitor

A compound having the formula

• or N-oxide, salt, stereoisomeric form, or ester thereof wherein
• R1 and R2 are, each independently, hydrogen, Het1, Het2 or Y or
• R1 and R2 generate a ring, said ring is 3 to 7 membered and may be saturated or unsaturated wherein the ring members are optionally substituted by hydroxy, wherein
• Y is —C (═O)—C1-6 alkyl-Het1 or —C(═O)—C1-6 alkyl-Het2 or —C(═O)—C1-6alkyl-amino-C1-C6alkyl optionally substituted by Het1 or Het2,
• Het1 as a group or part of a group is defined as a saturated or partially unsaturated monocyclic, bicyclic or tricyclic heterocycle which contains one or more heteroatom ring members selected from nitrogen, oxygen or sulphur and which is optionally substituted on one or more carbon nitrogen atoms by C1-6alkyl, C1-6alkyloxy, aminoC1-6alkyl, C1-6alkyl-oxy-C1-6alkyl, benzyl, halogen, hydroxy, oxo, optionally mono- or disubstituted amino, optionally mono- or disubstituted aminoalkyl, nitro, acetyl, cyano, haloC1-6alkyl, carboxyl, C1-6alkoxycarbonyl, C1-6alkyl-Het2, C3-7cycloalkyl, optionally mono- or disubstituted aminocarbonyl, methylthio, methylsulfonyl, aryl or a saturated or partially unsaturated monocyclic, bicyclic or tricyclic cycle or heterocycle having 3 to 14 ring members;
• and wherein
• Het2 as a group or part of a group is defined as an aromatic monocyclic, bicyclic or tricyclic heterocycle which contains one or more heteroatom ring members selected from nitrogen, oxygen or sulphur and which is optionally substituted on one or more carbon atoms by C1-6alkyl, C1-6alkyloxy, aminoC1-6alkyl, halogen, hydroxy, optionally mono- or disubstituted amino, nitro, cyano, haloC1-6alkyl, carboxyl, C1-6alkoxycarbonyl, C3-7cycloalkyl, optionally mono- or disubstituted aminocarbonyl, methylthio, methylsulfonyl, aryl, Het1 or an aromatic monocyclic, bicyclic or tricyclic cycle or heterocycle having 3 to 12 ring members.