Substituted acetic acid derivatives

A compound having the formula:

• wherein:
• R1 is —OH, —OC1-C8 alkyl, or NH2;
• R2 and R3 are, independently, hydrogen, C1-C8 alkyl, —CH2—C3-C6 cycloalkyl, —CH2-pyridinyl, phenyl, or benzyl;
• R4 is hydrogen, C1-C8 alkyl, C3-C6 cycloalkyl, —CH2—C3-C6 cycloalkyl, phenyl, benzyl, heteroaryl, or —CH2-heteoraryl;
• X is
• wherein:
• R5 is hydrogen, C1-C8 alkyl, C3-C6 cycloalkyl, —CH2—C3-C6 cycloalkyl, phenyl, benzyl, heteroaryl, or —CH2-heteoraryl;
• R6 is hydrogen, C1-C8 alkyl, —(CH2)n—CH═CH2, —(CH2)n—CH═CH-alkyl, —(CH2)nC≡CH, —(CH2)nC≡CH-alkyl, aryl, (CH2)n-aryl, heteroaryl, (CH2)n-heteroaryl, —CO-aryl, —CO-heteroaryl, —CO-alkyl, —SO2-alkyl, —SO2-aryl, or —SO2-heteroaryl;
• R7 is —O(CH2)n-aryl or —O(CH2)n-heteroaryl;
• R8 and R9 are, independently, hydrogen, halogen, C1-C6 alkyl, C1-C3 perfluoroalkyl, —O—C1-C3 perfluoroalkyl, C1-C3 alkoxy, —OH, —NH2 or —NO2;
• and
• n is an integer from 0 to 5;
• or a pharmaceutically acceptable salt form thereof.