3-amino-1-arylpropyl indoles and AZA-substituted indoles and uses thereof

A compound of formula I:

• or a pharmaceutically acceptable salt thereof,
• wherein:
• p is 1 or 2;
• Y is CRe;
• Ar is indazolyl selected from indazol-4-yl, indazol-5-yl, indazol-6-yl, and indazol-7-yl, each optionally substituted;
• R1 is:
• (a) aryl selected from phenyl and naphthyl, each optionally substituted;
• or
• (b) heteroaryl selected from indolyl, indazolyl, pyridinyl, thienyl, furanyl, pyrimidinyl, pyridazinyl, pyrazinyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, imidazolyl, pyrazolyl, quinolinyl, isoquinolinyl, quinoxalinyl, benzothiazolyl, benzofuranyl, benzothiophenyl or benzoxazinyl, each optionally substituted;
• (c) optionally substituted arylalkyl;
• (d) optionally substituted heteroarylalkyl;
• (e) cycloalkyl;
• or
• (f) cycloalkylmethyl;
• R2 and R3 each independently is:
• (a) hydrogen;
• (b) alkyl;
• (c) hydroxyalkyl;
• (d) alkoxyalkyl;
• (e) benzyl;
• or
• (f) R2 and R3 together with the nitrogen to which they are attached may form an optionally substituted four to seven membered ring that optionally includes an additional heteroatom selected from N, O and S;
• or
• (g) one of R2 and R3 together with one of Ra and Rb and the atoms to which they are attached may form a five or six membered ring that optionally includes an additional heteroatom selected from O, N and S;
• Ra is:
• hydrogen;
• fluoro;
• or
• alkyl;
• Rb is:
• hydrogen;
• alkyl;
• hydroxy;
• alkoxy;
• fluoro;
• or
• hydroxyalkyl;
• Rc and Rd each independently is:
• hydrogen;
• or
• alkyl;
• or Rc and Rd together form ═O, ═S, or ═NRf, wherein Rf is hydrogen, alkyl, or
• —ORg, wherein Rg is hydrogen or alkyl;
• or one of R2 and R3 together with one of Rc and Rd together with the atoms to which they are attached may form a four to six membered ring that optionally includes an additional heteroatom selected from O, N and S;
• and
• Re is hydrogen or alkyl.