Functionally selective alpha2C adrenoreceptor agonists

A compound represented by the structural formula:

• or a pharmaceutically acceptable salt of said compound, wherein:
• J1, J2 and J3 are —C(R2)—;
• is a single or double bond;
• R1 is —(CH2)qNR7YR7′;
• Y is selected from the group consisting of —C(═O)—, —C(═O)NR7—, —C(═O)O—, —C(═NR7)NR7—, —S(O)p—, and —SO2NR7;
• R2 is independently selected from the group consisting of H, —OH, halo, and —CN, and alkyl and alkoxy optionally substituted with at least one R5;
• R3 is independently selected from the group consisting of H and alkyl and alkoxy optionally substituted with at least one R5;
• R4 is independently selected from the group consisting of H and alkyl;
• R5 is independently selected from the group consisting of H, halo, —OH, —CN, —NO2, —NR7R7′, and —SR7, and alkyl, alkoxy, alkenyl, alkenyloxy, alkynyl, cycloalkyl, cycloalkoxy, aryl, aryloxy, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, and heterocyclylalkyl groups, each of which is optionally substituted with at least one of halo, —OH, —CN, —NO2, —NR7R7′, and —S(O)pR7 substituents;
• R7 is independently selected from the group consisting of H and alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, heterocyclyl, heteroaryl, and heteroarylalkyl groups, each of which is optionally substituted with at least one of halo, alkoxy, —OH, —CN, —NO2, —N(R11)2 and —S(O)pR11 substituents;
• R7′ is independently selected from the group consisting of selected from the group consisting of H and alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, heteroaryl, and heteroarylalkyl groups, each of which is optionally substituted with at least one of halo, —OH, —CN, —NO2, —N(R11)2, and —SR11 substituents;
• R11 is a moiety independently selected from the group consisting of H and alkyl, alkoxy, alkenyl, alkenyloxy, alkynyl, cycloalkyl, cycloalkoxy, aryl, aryloxy, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, and heterocyclylalkyl;
• m is 1-5;
• n is 1;
• p is 0-2;
• q is 0;
• w is 1-3;
• and
• z is 0.