Kv1.5 potassium channel inhibitors

A compound having Formula I:

• wherein R is optionally substituted phenyl;
• R1 is optionally substituted phenyl, optionally substituted C3-C7 cycloalkyl, or optionally substituted heteroaryl;
• R2 is hydrogen or is selected from:
• i) —SO2[C(R5aR5b)]jR4;
• ii) —C(O)[C(R5aR5b)]kR4;
• or
• iii) —[C(R5aR5b)]nR4;
• R3 is hydrogen or is selected from:
• i) C1-C4 linear or branched alkyl, or C3-C7 cycloalkyl;
• ii) —SO2[C(R5aR5b)]jR4;
• or
• iii) —[C(R5aR5b)]nR4;
• or
• R2 and R3 are taken together with the atom to which they are bound to form an optionally substituted ring having from 3 to 7 ring atoms optionally containing one or more additional heteroatom ring atoms selected from N, O, or S;
• R5a and R5b are each independently hydrogen or C1-C4 linear alkyl;
• R4 is selected from;
• i) hydrogen;
• ii) —N(R6aR6b);
• iii) —SO2R7;
• iv) —C(O)N(R8aR8b);
• v) optionally substituted C1-C6 linear or branched alkyl, or optionally substituted C3-C6 cycloalkyl;
• vi) optionally substituted C2-C6 linear or branched alkenyl;
• vii) optionally substituted C1-C6 linear or branched alkoxy;
• viii) optionally substituted C6 or C10 aryl;
• ix) optionally substituted C6 or C10 aryloxy;
• x) optionally substituted heteroaryl;
• xi) optionally substituted heterocycle;
• or
• xii) optionally substituted C(O)O(arylalkyl);
• R6a and R6b are each independently hydrogen, optionally substituted C1-C6 linear or branched alkyl, optionally substituted C3-C6 cycloalkyl, optionally substituted benzyl, optionally substituted phenyl, or —C(O)OR7a, or R6a and R6b are taken together with the atom to which they are bound to form a ring having from 3 to 7 ring atoms optionally containing one or more additional heteroatom ring atoms selected from N, O, or S;
• R7 is hydrogen, optionally substituted C1-C6 linear or branched alkyl, optionally substituted C3-C6 cycloalkyl, or N(R7a)2;
• R7a, at each occurrence, independently, is hydrogen, optionally substituted C1-C6 linear or branched alkyl, or optionally substituted C3-C6 cycloalkyl;
• R8a and R8b are each independently hydrogen, optionally substituted C1-C6 linear or branched alkyl, optionally substituted C3-C6 cycloalkyl, or R8a and R8b are taken together with the atom to which they are bound to form a ring having from 3 to 7 ring atoms optionally containing one or more additional heteroatom ring atoms selected from N, O, or S;
• L and L1 are, independently, —[C(R9aR9b)]m—;
• R9a and R9b are, at each occurrence, each independently hydrogen or methyl, or R9a and R9b are taken together with the atom to which they are bound to form a cyclopropyl ring;
• x and y are independently 0 or 1;
• m, at each occurrence, independently is 0 to 4;
• j, at each occurrence, independently is 0 to 4;
• and
• k and n, at each occurrence, are independently 0 to 3;
• or a pharmaceutically acceptable salt form thereof.