Imidazolidine derivatives
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsKazutaka Tachibana, Haruhiko Sato, Masateru Ohta, Mitsuaki Nakamura, Takuya Shiraishi, Ikuhiro Imaoka, Hitoshi Yoshino, Masahiro Nagamuta, Hiromitsu Kawata
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Abstract
The present invention provides a compound represented by formula (I): wherein n is an integer selected from 1 to 20, Q is A is cyano or the like; B is hydrogen, halogen, or the like; X1 and X2 are each independently selected from O and S; E is a C1-4 alkyl group; and R1, R2, R3 and R4 are each independently selected from a hydrogen atom and a C1-C6 alkyl group, and a drug, a pharmaceutical composition containing the compound, and the like.
Claims12
A compound represented by formula (I):
- wherein, n is an integer selected from 1 to 20, Q is
- A is cyano group, —COOR3, —CONR3R4, a C1-C4 alkyl group which may be substituted by one or more halogen atoms, or a nitro group;
- B is a hydrogen atom, a halogen atom, —OR3 or a C1-C4 alkyl group which may be substituted by one or more halogen atoms;
- X1 and X2 are independently selected from O and S;
- m is an integer selected from 0 to 3;
- E is independently a C1-C4 alkyl group;
- R1 and R2 are independently selected from a hydrogen atom, a C1-C6 alkyl group, and a C1-C6 alkylcarbonyl group;
- R3 and R4 are independently selected from a hydrogen atom and a C1-C6 alkyl group;
- with the proviso that when X1 is O and X2 is S, Q is not 4-cyano-3-trifluoromethylphenyl group,
- or a pharmaceutically acceptable salt, or a prodrug thereof.
A compound represented by formula (III):
- wherein, Q, X1, X2 n, Ra and Rb are as defined in cm 11.
Dependencies are inferred from the claim text.