2-amino-4,5-trisubstituted thiazolyl derivatives

A compound of formula

• a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof,
• wherein
• L is imidazothiazolyl;
• Q is C3-6cycloalkyl, phenyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, benzthiazolyl, benzoxazolyl, benzimidazolyl, indazolyl, or imidazopyridyl, each of said rings optionally being substituted with up to three substituents each independently selected from halo;
• hydroxy;
• cyano;
• carboxyl;
• azido;
• amino;
• mono- or di(C1-6alkyl)amino;
• C1-6alkylcarbonylamino;
• C1-6alkyl;
• C2-6alkenyl;
• C2-6alkynyl;
• C3-6cycloalkyl;
• C1-6alkyl substituted with hydroxy, C1-6alkyloxy, amino or mono- or di(C1-4alkyl)amino;
• C1-6alkyloxy;
• C1-6alkylthio;
• C1-6alkylcarbonyl;
• C1-6alkyloxycarbonyl;
• arylC1-6alkyloxy;
• aryloxy;
• polyhaloC1-6alkyl;
• polyhalo-C1-6alkyloxy;
• polyhaloC1-6alkylcarbonyl;
• piperidinylamino;
• 1-methyl-4-piperidinylamino;
• morpholinyl, C1-4alkyl-S(═O)n— or H2N—S(═O)n—;
• and n is an integer of 1 or 2;
• or
• Q is a radical of formula
• and wherein
• r is an integer from 1 to 3;
• q is an integer from 1 to 4;
• X and Y are each independently O, NR3, CH2 or S, with R3 being hydrogen or C1-4alkyl;
• W is O or NR4, with R4 being hydrogen or C1-4 alkyl;
• and wherein aryl is phenyl, optionally substituted with up to five substituents each independently selected from halo, hydroxy, C1-6alkyl, polyhaloC1-6alkyl, C1-6alkyloxy, C1-6alkylthio, cyano, nitro, amino or mono- or di(C1-6alkyl)amino;
• and
• Z is halo;
• C1-6alkyl;
• C1-6alkyl substituted with amino;
• C1-6alkyl substituted with hydroxy;
• 4-piperidinylaminomethyl;
• or 1-methyl-4-piperidinylaminomethyl.