DPP IV inhibitors

A pharmaceutical composition comprising:

• a compound of formula (I)
• wherein
• R1 is CN,
• R2 is —C(R3,R4)—(CH2)n—R5, —C(R3,R4)—CH2—NH—R6, —C(R3,R4)—CH2—O—R7;
• or tetralinyl, tetrahydroquinolinyl or tetrahydroisoquinolinyl, which tetralinyl, tetrahydroquinolinyl or tetrahydroisoquinolinyl group can be unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of lower-alkyl, lower-alkoxy, halogen, CN, and CF3,
• R3 is hydrogen, lower-alkyl, benzyl, hydroxybenzyl or indolylmethylene,
• R4 is hydrogen or lower-alkyl, or
• R3 and R4 are bonded to each other to form a ring together with the carbon atom to which they are attached and —R3—R4— is —(CH2)2-5—,
• R5 is 5-membered heteroaryl, bi- or tricyclic heterocyclyl, or aminophenyl;
• which can be unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of lower-alkyl, lower-alkoxy, halogen, CN, CF3, trifluoroacetyl, thiophenyl, phenyl, heteroaryl and monocyclic heterocyclyl, which phenyl, heteroaryl or monocyclic heterocyclyl can be unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of lower-alkyl, lower-alkoxy, benzyloxy, halogen, CF3, CF3—O, CN and NH—CO—lower-alkyl,
• R6 is a) pyridinyl or pyrimidinyl, which is substituted with 1 to 3 substituents independently selected from the group consisting of aryl and heteroaryl, which aryl or heteroaryl group can be unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of lower-alkyl, lower-alkoxy, halogen, CN, and CF3,
• or b) 5-membered heteroaryl or bi- or tricyclic heterocyclyl, which 5-membered heteroaryl or bi- or tricyclic heterocyclyl can be unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of lower-alkyl, carbonyl, aryl and heteroaryl, which aryl or heteroaryl group can be unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of lower-alkyl, lower-alkoxy, halogen, CN, and CF3, and which carbonyl group can be unsubstituted or substituted with lower -alkyl, lower-alkoxy, halogen, CN, CF3, aryl, or heteroaryl, which aryl or heteroaryl group can be unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of lower-alkyl, lower-alkoxy, halogen, CN, and CF3,
• R7 is aminophenyl, naphthyl or quinolinyl, which can be unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of lower-alkyl, lower-alkoxy, halogen, CN and CF3,
• X is C(R8,R9) or S,
• R8 and R9 independently from each other are H or lower-alkyl,
• n is 0, 1 or 2,
• and pharmaceutically acceptable salts thereof;
• and a pharmaceutically acceptable carrier and/or adjuvant.