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US 7,803,814 B2Granted
Tricyclic steroid hormone nuclear receptor modulators
AssigneeEli Lilly and Company
InventorsKonstantinos Gavardinas, Jonathan Edward Green, Prabhakar Kondaji Jadhav, Donald Paul Matthews
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Abstract
The present invention provides a compound of the formula (I): or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly congestive heart disease, hypertension, rheumatoid arthritis or inflammation, comprising administering to a patient in thereof an effective amount of a compound of Formula (I).
Claims15
A compound of the formula:
- wherein,
- Y represents CH2 or O;
- R1 and R2 each independently represent hydrogen or fluoro
- R3 represents a group of the formula:
- wherein Z represents (CH2)n or —CR4R5-CH2-;
- n represents 0-3;
- and
- Het represents a group of the formula:
- R4 and R5 each independently represent at each occurrence hydrogen or methyl;
- R6 and R7 each independently represent at each occurrence hydrogen, methyl, or ethyl;
- provided Formula I does not represent a compound selected from the group consisting of
- or a pharmaceutically acceptable salt thereof.
9 more elements
Dependencies are inferred from the claim text.