US 7,803,810 B2 · Inhibitors

Abstract

Compounds of formula (I), combinations and uses thereof for disease therapy, or a pharmaceutically acceptable salt or solvate thereof, including all tautomers, stereoisomers and polymorphs thereof wherein: R1 represents C2-8alkyl; C2-8alkenyl; —(C1-6alkyl)-aryl; —(C1-6alkyl)-heteroaryl; —(C1-6alkyl)-carbocyclyl; —(C1-6alkyl)-heterocyclyl; -aryl; -heteroaryl; -carbocyclyl or -heterocyclyl; wherein said aryl or heteroaryl groups may be optionally substituted by one or more substituents selected from, C1-4alkyl, C1-4-fluoroalkyl, C1-4alkoxy, C1-4-fluoroalkoxy, hydroxy, —SO2(C1-4alkyl), —SO2N(C1-4alkyl)(C1-4alkyl), —SOC1-4alkyl, —SOC3-6cycloalkyl —C(O)O(C1-4alkyl), benzyloxy and phenyl; and wherein said carbocyclyl and heterocyclyl groups may be optionally substituted by one or more substituents selected from —C1-4 alkyl, —C1-4 alkoxy, hydroxyl, halogen and oxo; R2 represents H; C1-4alkyl or halogen; R3 represents H; C1-4alkyl or halogen; and R4 represents H; C1-4alkyl or halogen.

Claims19

Dependent claims

A compound of formula (I),

or a pharmaceutically acceptable salt thereof, wherein:
R1 represents C2-8alkyl;
C2-8alkenyl;
—(C1-6alkyl)-aryl;
—(C1-6alkyl)-heteroaryl;
—(C1-6alkyl) -carbocyclyl;
—(C1-6alkyl)-heterocyclyl;
-aryl;
-heteroaryl;
-carbocyclyl or -heterocyclyl;
wherein said aryl or heteroaryl groups may be optionally substituted by one or more substituents selected from, C1-4alkyl, C1-4fluoroalkyl, C1-4alkoxy, C1-4fluoroalkoxy, hydroxy, —SO2(C1-4alkyl), —SO2N(C1-4alkyl)(C1-4alkyl), SOC1-4alkyl, —SOC3-6cycloalkyl, —C(O)O(C1-4alkyl), benzyloxy and phenyl;
and wherein said carbocyclyl and heterocyclyl groups may be optionally substituted by one or more substituents selected from —C1-4 alkyl, —C1-4 alkoxy, hydroxyl, halogen and oxo;
R2 represents H;
C1-4alkyl or halogen;
R3 represents H;
C1-4alkyl or halogen;
and
R4 represents H;
C1-4alkyl or halogen.

16 more elements

Dependencies are inferred from the claim text.

Inhibitors

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Inhibitors

Life of this patent

Abstract

Claims19