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US 7,803,799 B2Granted
Selenophene compounds
AssigneeNational Health Research Institutes
InventorsKak-Shan Shia, Jing-Po Tsao, Chia-Liang Tai, Wan-Ping Hsieh, Ming-Shiu Hung, Jen-Shin Song, Yu-Sheng Chao
Life of this patent
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Abstract
This invention relates to selenophene compounds of formula (I) shown below. Each variable in formula (I) is defined in the specification. These compounds can be used to treat cannabinoid-receptor mediated disorders.
Claims10
A compound of formula (I):
- wherein
- R1 is C3-C20 cycloalkyl, C3-C20 cycloalkenyl, C1-C20 heterocycloalkyl, C1-C20 heterocycloalkenyl, aryl, or heteroaryl;
- R2 is C(O)NRaRb, in which each of Ra and Rb, independently, is H, C1-C10 alkyl, C3-C20 cycloalkyl, C1-C20 heterocycloalkyl, aryl, or heteroaryl;
- and
- each of R3, R4, R5, and R6, independently, is H, halo, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C20 cycloalkyl, C3-C20 cycloalkenyl, C1-C20 heterocycloalkyl, C1-C20 heterocycloalkenyl, aryl, or heteroaryl.
2 more elements
A method for treating a cannabinoid-receptor mediated disorder, comprising administering to a subject in need thereof an effective amount of a compound of formula (I):
- wherein
- R1 is C3-C20 cycloalkyl, C3-C20 cycloalkenyl, C1-C20 heterocycloalkyl, C1-C20 heterocycloalkenyl, aryl, or heteroaryl;
- R2 is C(O)NRaRb, in which each of Ra and Rb, independently, is H, C1-C10 alkyl, C3-C20 cycloalkyl, C1-C20 heterocycloalkyl, aryl, or heteroaryl;
- and
- each of R3, R4, R5, and R6, independently, is H, halo, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C20 cycloalkyl, C3-C20 cycloalkenyl, C1-C20 heterocycloalkyl, C1-C20 heterocycloalkenyl, aryl, or heteroaryl.
2 more elements
Dependencies are inferred from the claim text.